The Istanbul-based Kandilli Observatory said the quake in Kutahya province occurred at 11.15pm local time and was centred near the town of Simav.
AHaber TV said there were casualties at a hospital in Simav, but did not say how many. Ambulances reportedly ferried the injured for treatment.
At least six aftershocks, the strongest with a preliminary magnitude of 4.6, shook Kutahya, the observatory added.
NTV television cited a resident in Simav as saying some buildings are damaged and most of the town is without electricity.
The quake toppled the minaret of a mosque in the town of Pazarcik, TGRT television said.
Hatice Unlu, a resident of the town of Tavsanli in Kutahya province, told TV8 channel that the tremor caused major panic.
Casualties have been reported after an earthquake with a preliminary magnitude of 6.0 hit western Turkey
"Furniture swayed and plates fell on the floor. I struggled to save my computer before rushing out," Mr Unlu said. "We fear to return home."
Idris Bal, a politician who was in Kutahya, said he was on the fifth floor of an apartment building when the quake hit. "It was so strong that we could not even move in the first few seconds," he told NTV television.
The quake was felt as far away as the Aegean city of Izmir, the north-western city of Bursa, Istanbul and the city of Edirne, close to the Greek and Bulgarian borders.
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